Cryo-Electron Microscopy Reveals Molecules in Ever Greater Detail

The molecular visualization technique known as cryo-electron microscopy (cryo-EM) was recently named the “2015 Method of the Year” by the journal Nature Methods. In a recent blog post, NIH Director Francis Collins explains how the technology works and just how rapidly it has advanced. He writes, “Today’s cryo-EM is so powerful that researchers can almost make out individual atoms!” He also notes, “These dramatic advances serve as a reminder of the ways in which basic technological innovation can open new realms of scientific possibility.”

We fund many scientists who are developing and applying cryo-EM to bring the details of biological structures into unprecedented focus. Here are two examples of their work and its potential impact. Continue reading