NIGMS’ Small Business Technology Transfer (STTR) program works toward more effective methods for patient screening, diagnosis, and treatment.
Translating lab discoveries into health care products requires large investments of time and resources. Through the STTR Regional Technology Transfer Accelerator Hubs for IDeA States program, NIGMS helps researchers interested in transitioning their discoveries and/or inventions into products. Here are the stories of three researchers working with the XLerator Hub, which funds projects in the southeastern United States and Puerto Rico.
Ending Diagnostic Delays for Endometriosis
Dr. Idhaliz Flores-Caldera.
Credit: Courtesy of Dr. Flores-Caldera.
Idhaliz Flores-Caldera, Ph.D., a professor of basic sciences and OB-GYN at Ponce Health Sciences University in Puerto Rico, has studied endometriosis for nearly 20 years. Endometriosis occurs when endometrial tissue, which typically lines the uterus, grows elsewhere in the body. Dr. Flores-Caldera first had the idea for a noninvasive diagnostic test for the disorder about 10 years ago. But it was only when she learned about funding opportunities from the XLerator Hub that she saw a path to validating her preliminary research findings and eventually commercializing her test.
Dr. Flores-Caldera applied for and was accepted into the hub’s proof-of-concept program, Ideas to Products, which funds researchers to flesh out ideas they want to commercialize. “I am very appreciative of how the program has provided me with tools and knowledge about commercializing a product and the process of patenting a product,” she says. “In general, scientists aren’t educated on this important topic.”
Continue reading “Accelerating the Development of Tests for Endometriosis and Cancer”
NIGMS, in collaboration with Scholastic, has developed a collection of free biology and health activities on the educational app Kahoot! You can play them alone, with friends, or with a class of students. Four Kahoots! are currently available:
Continue reading “Engage Learners in Science and Health With Our Kahoots!”
ACTIV clinical trials will evaluate the safety and efficacy of COVID-19 treatments and vaccines. Credit: iStock.
Since the virus that causes COVID-19, known as SARS-CoV-2, was first reported in late 2019, scientists have launched hundreds of studies on strategies for diagnosis, prevention, and treatment. To prioritize the most promising vaccine and therapeutics candidates, streamline clinical trials, and coordinate regulatory processes, the National Institutes of Health (NIH) and the Foundation for the NIH have established the Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) partnership. ACTIV brings together eight government entities, 20 biopharmaceutical companies, and four nonprofit organizations.
The public-private partnership provides infrastructure, subject matter expertise, and funding to efficiently bring the most promising therapeutics and vaccines into clinical trials. Five ACTIV therapeutic trials are underway. NIGMS-supported Institutional Development Award Program Infrastructure for Clinical and Translational Research (IDeA-CTR) networks reach historically underserved areas and populations, which are important participants in such trials.
Continue reading “COVID-19 Vaccine and Therapeutic Trials ACTIV-ate in West Virginia”
Spike proteins on the surface of a coronavirus. Credit: David Veesler, University of Washington.
Since the start of the COVID-19 pandemic, researchers from many areas of biomedical science have worked together to learn how this new disease affects the human body, how to prevent its spread, and how to treat it. Severe cases of COVID-19 and cases of sepsis share many symptoms. Sepsis is the body’s overactive and extreme response to an infection. It’s unpredictable and can progress rapidly. Without prompt treatment, it can lead to tissue damage, organ failure, and death.
Sepsis has similarities with some cases of COVID-19, most likely because the two conditions trigger the same reactions at the cellular level. Researchers have studied these reactions in sepsis for many years.
“When we look back on 2020 and the speed with which progress was made against COVID-19, two features will stand out,” says John Younger, M.D., a member of the NIGMS Advisory Council who recently co-chaired a working group on advancing sepsis research. “The first is how quickly the biotechnology community came together to develop vaccine candidates. The second, and arguably the most immediately impactful, is how caregivers and clinical researchers were able to rapidly refine the care of COVID-19 patients based on decades of experience with sepsis.”
This post highlights a few of the many sepsis researchers supported by NIGMS who are applying their expertise to COVID-19.
Continue reading “Fight Against COVID-19 Aided by Sepsis Researchers”
When someone mentions aging, you may think of visible changes, like graying hair. Scientists can see signs of aging in cells, too. Understanding how basic cell processes are involved in aging is a first step to help people lead longer, healthier lives. NIGMS-funded researchers are discovering how aging cells change and applying this knowledge to health care.
Discovering the Wisdom of Worms
with a ribosomal protein glowing red and muscle fibers glowing green. Credit: Hannah Somers, Mount Desert Island Biological Laboratory.
Aric Rogers, Ph.D., and Jarod Rollins, Ph.D., assistant professors of regenerative biology and medicine at Mount Desert Island (MDI) Biological Laboratory in Bar Harbor, Maine, are investigating aging by studying a tiny roundworm, Caenorhabditis elegans. Researchers often study C. elegans because, though it may seem drastically different from humans, it shares many genes and molecular pathways with us. Plus, its 2- to 3-week lifespan enables researchers to quickly see the effects of genetic or environmental factors on aging.
Drs. Rogers and Rollins investigate how C. elegans expresses genes differently under dietary restriction, enabling it to live longer. Understanding how genes are expressed when organisms live an extended life sheds light on the genetics underlying aging. This information could help researchers develop drugs or behavior modification programs that prolong life and delay the onset of age-related diseases such as heart disease, diabetes, cancer, and dementia.
Continue reading “Teaching Old Cells New Tricks: Insights Into Molecular-Level Aging”
Cover of Pathways
NIGMS and Scholastic bring you our latest issue of Pathways, which focuses on superbugs—infectious microbes that can’t be fought off with medicines. Viruses that can’t be prevented with vaccines, such as the common cold, and antibiotic-resistant bacteria both fall into this category.
Pathways, designed for students in grades 6 through 12, is a collection of free resources that teaches students about basic science and its importance to health, as well as exciting research careers.
Continue reading “Pathways: The Superbug Issue”
Sepsis is the body’s overactive and extreme response to an infection. It’s unpredictable, can progress rapidly, and affects more than 1.7 million people in the United States each year. Without prompt treatment, it can lead to tissue damage, organ failure, and death. NIGMS supports state-of-the-art sepsis research, including the development of rapid diagnostics and new therapeutics. September is Sepsis Awareness Month, and we’re highlighting a few resources that offer more information about this condition.
Our infographic provides details at a glance on basic statistics and the future of sepsis research. It’s also available in Spanish.
Continue reading “Shedding Light on Sepsis”
As part of its commitment to cultivate a diverse and inclusive scientific workforce, NIGMS continues to nurture relationships between teaching institutions and American Indian communities nationwide to ignite student interest in biomedical science and encourage research careers. This post highlights one such collaboration between NIGMS-supported centers at Montana State University (MSU) in Bozeman and the Blackfeet Nation, a tribe of nearly 18,000 members that’s one of the largest in the United States.
Neha John-Henderson, Ph.D., Montana State University. Credit: Kelly Gotham.
Neha John-Henderson, Ph.D. , an MSU assistant professor of psychology, first met Blackfeet Community College (BCC) students through Agnieszka Rynda-Apple, Ph.D., an MSU assistant professor of microbiology and immunology who already had a working relationship with the Blackfeet community. For about a year, Drs. John-Henderson and Rynda-Apple visited BCC interns and faculty supervisor Betty Henderson-Matthews monthly to help them interpret data collected for a student-developed project. While completing this project on the link between stress and health on the Blackfeet reservation, the researchers developed relationships with the students and faculty. They listened closely to the students’ stories, experiences, and career aspirations.
Continue reading “NIGMS Centers Build Relationships with Blackfeet Students and Collaborate on Inflammation Research”
What Is Computer Modeling and How Does It Work?
Recent news headlines are awash in references to “modeling the spread” and “flattening the curve.” You may have wondered what exactly this means and how it applies to the COVID-19 pandemic. Infectious disease modeling is part of the larger field of computer modeling. This type of research uses computers to simulate and study the behavior of complex systems using mathematics, physics, and computer science. Each model contains many variables that characterize the system being studied. Simulation is done by adjusting each of the variables, alone or in combination, to see how the changes affect the outcomes. Computer modeling is used in a wide array of applications, from weather forecasting, airplane flight simulation, and drug development to infectious disease spread and containment.
Continue reading “The Science of Infectious Disease Modeling”
Sepsis is a serious medical condition caused by an overwhelming response to infection that damages tissues and organs. It’s unpredictable, progresses quickly, can strike anyone, and is a leading cause of hospital-related deaths. In the U.S. alone, nearly 270,000 people die each year from sepsis. Those who survive sepsis often end up in the hospital again, and some have long-term health complications. Early treatment is key for many patients to survive sepsis, yet doctors can’t easily diagnose it because it’s so complex and each patient is different.
Despite decades of research, sepsis remains a poorly understood condition with limited diagnostic tools and treatment. To tackle these obstacles, scientists Vincent Liu, Christopher Seymour, and Hallie Prescott have started using a “big data” approach, which relies on complex computer programs to sift through huge amounts of information. In this case, the computers analyze data such as demographic information, vital signs, and routine blood tests in the electronic health records of sepsis patients. The goal is to find patterns in the data that might help doctors understand, predict, and treat sepsis more effectively.
Continue reading “Sepsis: Using Big Data to Cut a Killer Down to Size”