As computers have advanced over the past few decades, researchers have been able to work with larger and more complex datasets than ever before. The science of using computers to investigate biological data is called bioinformatics, and it’s helping scientists make important discoveries, such as finding versions of genes that affect a person’s risk for developing various types of cancer. Many scientists believe that almost all biologists will use bioinformatics to some degree in the future.
However, bioinformatics isn’t always included in college biology programs, and many of today’s researchers received their training before bioinformatics was widely taught. To address these gaps, the bioinformatics cores of the five Northeast IDeA Networks of Biomedical Research Excellence (INBREs)—located in Maine, Rhode Island, Delaware, Vermont, and New Hampshire—have worked together to offer basic bioinformatics training to students and researchers. The collaboration started in 2009 with a project where researchers sequenced the genome of a fish called the little skate (Leucoraja erinacea) and used the data to develop trainings.
A fruit fly expressing GFP. Credit: Jay Hirsh, University of Virginia.
During the holiday season, twinkling lights are a common sight. But no matter what time of the year, you can see colorful glows in many biology labs. Scientists have enabled many organisms to light up in the dark—from cells to fruit flies and Mexican salamanders. These glowing organisms help researchers better understand basic cell processes because their DNA has been edited to express molecules such as green fluorescent protein.
Jennifer Doudna, Ph.D. Credit: University of California, Berkeley.
The 2020 Nobel Prize in Chemistry was awarded to Jennifer Doudna, Ph.D., and Emmanuelle Charpentier, Ph.D., for the development of the gene-editing tool CRISPR. Dr. Doudna shared her thoughts on the award and answered questions about CRISPR in a live chat with NIH Director Francis S. Collins, M.D., Ph.D. Here are a few highlights from the interview.
Q: How did you find out that you won the Nobel Prize?
A: It’s a little bit of an embarrassing story. I slept through a very important phone call and finally woke up when a reporter called me. I was just coming out of a deep sleep, and the reporter was asking, “What do you think about the Nobel?” And I said, “I don’t know anything about it. Who won it?” I thought they were asking for comments on somebody else who won it. And she said, “Oh my gosh! You don’t know! You won it!”
Sudden changes to our schedules, like the end of daylight saving time this Sunday or flying across time zones, often leave us feeling off kilter because they disrupt our bodies’ circadian rhythms. Circadian rhythms are physical, mental, and behavioral changes that follow a daily cycle. When these “biological clocks” are disrupted, our bodies eventually readjust. However, some people have conditions that cause their circadian rhythms to be permanently out of sync with their surroundings.
If you’re looking for ways to engage students in science this school year, NIGMS offers a range of free resources that can help. All of our STEM materials are online and print-friendly, making them easy to use for remote teaching.
Pathways , developed in collaboration with Scholastic, is aligned with STEM and ELA education standards for grades 6 through 12. Materials include:
Student magazines with corresponding teaching guides
Related lessons with interactives
Cover of Pathways student magazine, third issue.
Available lessons examine basic science careers, regeneration, and circadian rhythms.
Note to our Biomedical Beat readers: Echoing the sentiments NIH Director Francis Collins made on his blog, NIGMS is making every effort during the COVID-19 pandemic to keep supporting the best and most powerful science. In that spirit, we’ll continue to bring you stories across a wide range of NIGMS topics. We hope these posts offer a respite from the coronavirus news when needed.
Mitosis is fundamental among all organisms for reproduction, growth, and cell replacement. When a cell divides, it’s vital that the two new daughter cells maintain the same genes as the parent.
In one step of mitosis, chromosomes are segregated into two groups, which will go into the two new daughter cells. But if the chromosomes don’t divide properly, one daughter cell may have too many and the other too few. Having the wrong number of chromosomes, a condition called aneuploidy, can trigger cells to grow out of control.
An illustration of chromosomes being segregated equally and unequally during mitosis. Credit: Deluca Lab, Colorado State University.
How chromosome segregation errors disrupt cell division is an important area of research. Although it’s been studied for decades, new aspects are still being uncovered and much remains unknown. NIGMS-funded scientists are studying different aspects of mitosis and chromosome segregation. Understanding the details can provide vital insight into an essential biological process and may also be the key to developing better drugs for cancer and other diseases.
If you’re looking for engaging ways to teach science from home, NIGMS offers a range of resources that can help.
A SEPA-funded resource about microbes. Credit: University of Nebraska, Lincoln.
Our Science Education and Partnership Award (SEPA) webpage features free, easy-to-access STEM and informal science education projects for pre-K through grade 12. Aligned with state and national standards for STEM teaching and learning, the program has tools such as:
Curricula and lesson plans
Students can learn about sleep, cells, growth, microbes, a healthy lifestyle, genetics, and many other subjects.
Sohini Ramachandran, Brown University. Credit: Danish Saroee/Swedish Collegium for Advanced Study.
Recent advances in computing enable researchers to explore the life sciences in ways that would have been impossible a few decades ago. One new tool is the ability to sequence genomes, revealing people’s full DNA blueprints. The collection of more and more genetic data allows researchers to compare the DNA of many people and observe variations, including those shared by people with a common ancestry.
Sohini Ramachandran , Ph.D., is director of the Center for Computational Molecular Biology and associate professor of biology and computer science at Brown University in Providence, Rhode Island. She is also a recent recipient of the Presidential Early Career Award for Scientists and Engineers (PECASE). Dr. Ramachandran researches the causes and consequences of human genetic variations using computer models. Starting with genomic data from living people, her lab applies statistical methods, mathematical modeling, and computer simulations to discover how human populations moved and changed genetically over time.
Regeneration is the natural process of replacing or restoring cells that have been lost or damaged due to injury or disease. A few animals can regrow entire organs or other body parts, but most have limited abilities to regenerate.
in the field of regenerative medicine study how some animals are able to
rebuild lost body parts. By better understanding these processes and learning
how to control them, researchers hope to develop new methods to treat injuries
and diseases in people.
Take this quiz to test what you know about regeneration and regenerative medicine. Then check out our Regeneration fact sheet and the regeneration issue of Pathways, a teaching resource produced in collaboration with Scholastic.
Over the past 12 months, we’ve explored a variety of topics in genetics, cell biology, chemistry, and careers in the biomedical sciences. As we ring in the new year, we bring you our top three posts of 2019. If your favorite is missing, let us know what it is in the comments section below!
Hawaiian bobtail squid. Credit: Dr. Satoshi Shibata.
Studying research organisms, such as those featured in this post, teaches us about ourselves. These amazing creatures, which have some traits similar to our own, may hold the key to preventing and treating an array of complex diseases.