Recognition for CRISPR Gene-Editing Tool

The CRISPR gene-editing tool was recognized today by Science magazine as its “breakthrough of the year.” We support a number of researchers working in this exciting area and have featured it on this blog. To learn more about this exceptionally promising new method, see below for our illustrated explanation of the CRISPR system and its possible applications.

How the CRISPR System Works

Illustration of CRISPR system

The CRISPR system has two components joined together: a finely tuned targeting device (a small strand of RNA programmed to look for a specific DNA sequence) and a strong cutting device (an enzyme called Cas9 that can cut through a double strand of DNA).

CRISPR system in a cell

Once inserted into a cell, the CRISPR machine locates the target DNA sequence. CRISPR’s RNA recognizes and binds to the target DNA (circled in black).

The Cas9 enzyme cuts both strands of the DNA.

New genetic material incorporated into the broken DNA

Researchers can introduce new genetic material, which the cell automatically incorporates into the gap when it repairs the broken DNA.

Among its many possible applications, the CRISPR system could be used to:
• Add a new gene that enables the organism to produce a pharmaceutical product (a biotechnology technique).
• Help treat genetic diseases.
• Create tailor-made model organisms to study human diseases.
• Help produce replacements for damaged or diseased tissues and organs.

3 comments on “Recognition for CRISPR Gene-Editing Tool

  1. Emily Carlson:

    Nos congratulamos, y ofrecemos nuestras oraciones para que sean bendecidos los investigadores que trabajan en esta área emocionante que han conseguido este Gran Avance del Año.
    Pido por favor información acerca de este método nuevo excepcionalmente prometedor, u otro vigente, si también puede tener o tiene como aplicación al Cavum Septum Pellucidum y la Ezquizofrenia.
    Muy agradecido por su información.
    Jorge Guzmán

  2. This is fantastic. I hope it will work for chronic granulomatous disease (CGD). We (the CGD Association) can give small grants for CRISPR research.

  3. The discovery of the ‘CRISPER EDITING TOOL’ is fantastic. This will open a new horizon in the field of ‘ OMIC ‘ disorders.

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