Category: Being a Scientist

COVID-19 Vaccine and Therapeutic Trials ACTIV-ate in West Virginia

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Hands in medical gloves drawing liquid from a vial into a syringe with a model of SARS-CoV-2 in the background. ACTIV clinical trials will evaluate the safety and efficacy of COVID-19 treatments and vaccines. Credit: iStock.

Since the virus that causes COVID-19, known as SARS-CoV-2, was first reported in late 2019, scientists have launched hundreds of studies on strategies for diagnosis, prevention, and treatment. To prioritize the most promising vaccine and therapeutics candidates, streamline clinical trials, and coordinate regulatory processes, the National Institutes of Health (NIH) and the Foundation for the NIH have established the Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) partnership. ACTIV brings together eight government entities, 20 biopharmaceutical companies, and four nonprofit organizations.

The public-private partnership provides infrastructure, subject matter expertise, and funding to efficiently bring the most promising therapeutics and vaccines into clinical trials. Five ACTIV therapeutic trials are underway. NIGMS-supported Institutional Development Award Program Infrastructure for Clinical and Translational Research (IDeA-CTR) networks reach historically underserved areas and populations, which are important participants in such trials.

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Fight Against COVID-19 Aided by Sepsis Researchers

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Oblong light-blue structures with red spots in the middle connected to the surface of a sphere. Spike proteins on the surface of a coronavirus. Credit: David Veesler, University of Washington.

Since the start of the COVID-19 pandemic, researchers from many areas of biomedical science have worked together to learn how this new disease affects the human body, how to prevent its spread, and how to treat it. Severe cases of COVID-19 and cases of sepsis share many symptoms. Sepsis is the body’s overactive and extreme response to an infection. It’s unpredictable and can progress rapidly. Without prompt treatment, it can lead to tissue damage, organ failure, and death.

Sepsis has similarities with some cases of COVID-19, most likely because the two conditions trigger the same reactions at the cellular level. Researchers have studied these reactions in sepsis for many years.

“When we look back on 2020 and the speed with which progress was made against COVID-19, two features will stand out,” says John Younger, M.D., a member of the NIGMS Advisory Council who recently co-chaired a working group on advancing sepsis research. “The first is how quickly the biotechnology community came together to develop vaccine candidates. The second, and arguably the most immediately impactful, is how caregivers and clinical researchers were able to rapidly refine the care of COVID-19 patients based on decades of experience with sepsis.”

This post highlights a few of the many sepsis researchers supported by NIGMS who are applying their expertise to COVID-19.

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Career Conversations: Q&A with Organic Chemist Osvaldo Gutierrez

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Osvaldo Gutierrez, Ph.D., was born in Rancho Los Prietos, a small town in central Mexico where his grandmother served as a midwife. Seeing how his grandmother helped people through her work inspired Dr. Gutierrez to pursue a career where he, too, could help people. His family emigrated to the United States when he was young. Despite challenges he faced in a new country, he graduated from high school, attended community college, and was accepted to the University of California, Los Angeles. He originally planned to become a medical doctor, but an undergraduate research experience sparked an interest in chemistry, and he ultimately earned a Ph.D. in the field.

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Year in Review: Our Top Three Posts of 2020

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Over the year, we dove into the inner workings of cells, interviewed award-winning researchers supported by NIGMS, shared a cool collection of science-themed backgrounds for video calls, and more. Here, we highlight three of the most popular posts from 2020. Tell us which of this year’s posts you liked best in the comments section below!

The Science of Infectious Disease Modeling

Oblong light-blue structures with red spots in the middle connected to the surface of a sphere. Spike proteins on the surface of a coronavirus. Credit: David Veesler, University of Washington.

What does “modeling the spread” (or “flattening the curve”) mean, and how does it apply to infectious diseases such as COVID-19? Learn about the science of infectious disease modeling and how NIGMS supports scientists in the field.

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Expert Advice on Starting a Lab

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During our Starting Your Own Lab webinar, attendees asked so many insightful questions that we ran out of time to respond to all of them. So we asked nine NIGMS early career investigators to tackle the most popular ones in short videos, which were featured on our social media. Now, you can watch the whole series on our YouTube channel.

1. What advice do you have for postdocs searching for a faculty position?
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Preparing Students in Puerto Rico for Biomedical Careers

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“There’s knowledge to seize in Puerto Rico, and our program is letting students know that they have a really important role to play in solving local problems, that they are part of the solution,” says Isar P. Godreau, Ph.D., a researcher at the University of Puerto Rico (UPR) Cayey Institute of Interdisciplinary Research.

Dr. Godreau, along with fellow researchers Mariluz Franco-Ortiz, Ph.D., at UPR Cayey Institute of Interdisciplinary Research, and Raymond Louis Tremblay, Ph.D., at UPR Humacao, directs an NIGMS Innovative Programs to Enhance Research Training (IPERT) grant. The UPR IPERT supports undergraduates throughout the university’s 11 campuses.

Resources Reach Thousands

Dr. Ortiz standing with other standing and kneeling students in a classroom, smiling and waving. Dr. Franco-Ortiz (second from right) with students during a Coaching for Resiliency workshop session. Credit: Ivonne Bayron-Huertas, Ph.D.

Furthering NIGMS’ goals to create a highly skilled and diverse biomedical workforce, UPR IPERT provides undergraduate students from economically disadvantaged families with skills development and mentoring opportunities. One of the program’s main components is a series of Coaching for Resiliency workshops, which cover topics such as dealing with stress, managing family expectations, and handling financial challenges. A coach leads each group that includes about 10 to 15 first-year students and half as many second-year or higher students who act as peer mentors.

The coaching sessions help students connect with one another and with mentors. “One of the main accomplishments beyond the numbers is the power of networking,” says Dr. Franco-Ortiz. “The power of networking at different levels—from student mentors and faculty mentors at the UPR campus as well as abroad—is so crucial in terms of helping students who are looking for next steps.”

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Q&A With Nobel Laureate and CRISPR Scientist Jennifer Doudna

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A headshot of Dr. Doudna. Jennifer Doudna, Ph.D. Credit: University of California, Berkeley.

The 2020 Nobel Prize in Chemistry was awarded to Jennifer Doudna, Ph.D., and Emmanuelle Charpentier, Ph.D., for the development of the gene-editing tool CRISPR. Dr. Doudna shared her thoughts on the award and answered questions about CRISPR in a live chat with NIH Director Francis S. Collins, M.D., Ph.D. Here are a few highlights from the interview.

Q: How did you find out that you won the Nobel Prize?

A: It’s a little bit of an embarrassing story. I slept through a very important phone call and finally woke up when a reporter called me. I was just coming out of a deep sleep, and the reporter was asking, “What do you think about the Nobel?” And I said, “I don’t know anything about it. Who won it?” I thought they were asking for comments on somebody else who won it. And she said, “Oh my gosh! You don’t know! You won it!”

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How I Got Here: A Webinar on Following Your Own Career Path

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There is no single avenue to a scientific career—the paths are as diverse as the people who pursue them. In a recent webinar, two NIGMS-supported researchers shared their unique journeys as scientists and their advice for those seeking careers in the field. The webinar is part of a series from NIGMS created for the research training community—students, postdocs, and faculty. Experts focus on topics from infectious disease modeling to virtual teaching and learning. 

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Pathways: The Superbug Issue

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Cover of Pathways student magazine showing blueish-green virus particles and text that reads, Stop the Spread of Superbugs (Yes, you can help!). Cover of Pathways student magazine.

NIGMS and Scholastic bring you our latest issue of Pathways, which focuses on superbugs—infectious microbes that can’t be fought off with medicines. Viruses that can’t be prevented with vaccines, such as the common cold, and antibiotic-resistant bacteria both fall into this category.

Pathways, designed for students in grades 6 through 12, is a collection of free resources that teaches students about basic science and its importance to health, as well as exciting research careers.

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Decades of Dedication: Angela Wandinger-Ness Recognized for Outstanding Mentoring

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“Each person has something that they uniquely want to do, and as a mentor, you have to help uncover that,” says Angela Wandinger-Ness, Ph.D., the Victor and Ruby Hansen Surface Endowed Professor in Cancer Cell Biology and Clinical Translation in the department of pathology at the University of New Mexico (UNM) School of Medicine. “You have to put opportunities in front of them. You see what excites them, and then you steer them.” Dr. Wandinger-Ness is among this year’s honorees of the Presidential Award for Excellence in Science, Mathematics and Engineering Mentoring (PAESMEM).

Dr. Wandinger-Ness, Amber Rauch, and Melanie Rivera standing together in a laboratory. Dr. Wandinger-Ness (left) with former undergraduate trainee Amber Rauch (center) and current Ph.D. trainee Melanie Rivera. Credit: Angela Wandinger-Ness, Ph.D.

The PAESMEM was established by the White House in 1995. This year, recipients were honored during a virtual awards ceremony. Each awardee received a grant from the National Science Foundation, which manages the PAESMEM on behalf of the White House Office of Science and Technology Policy.

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