Category: Being a Scientist

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Career Conversations: Q&A with Biomolecular Engineer Markita Landry

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A headshot of Dr. Landry.
Dr. Markita Landry. Credit: Vilcek Foundation.

“I have a hard time envisioning a career more exciting than science. It’s really magical to see an experimental result and, for a moment, be the only person in the universe to know something about the world,” says Markita Landry, Ph.D., an associate professor of chemical and biomolecular engineering at the University of California, Berkeley. In an interview, Dr. Landry shares with us her scientific journey, research with nanoparticles, and interests outside of the lab.

Q: What sparked your interest in science?

A: I was indirectly exposed to science growing up because my mom was in computer science, but I think moving to the United States is what made me very interested in it. My mother is Bolivian; my father is French-Canadian; and I grew up mostly in Quebec, Canada. When I was halfway through high school, we moved to the United States, and, for the first time, my classes were taught in English. I really gravitated to math and science because they made sense regardless of the language they were taught in.

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The Chemistry Clicked: Two NIGMS-Funded Researchers Receive Nobel Prize

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Since its creation in 1962, NIGMS has supported the work of the recipients of 94 Nobel Prizes—44 in physiology or medicine and 50 in chemistry. NIGMS-funded investigators perform cutting-edge basic research that is foundational to understanding normal life processes and disease. Such important breakthroughs in chemistry and biology often fuel more focused research that, years later, leads to important medical advances or products such as medicines or biotechnology tools.

Sketches of Drs. Carolyn R. Bertozzi and K. Barry Sharpless above their printed names.
Credit: Niklas Elmehed.

The most recent NIGMS-supported Nobel laureates are Carolyn R. Bertozzi, Ph.D., the Anne T. and Robert M. Bass Professor in the School of Humanities and Sciences at Stanford University in Stanford, California, and K. Barry Sharpless, Ph.D., the W.M. Keck Professor of Chemistry at the Scripps Research Institute in La Jolla, California. They, along with Morten Meldal, Ph.D., a professor of chemistry at the University of Copenhagen in Denmark, are being recognized with the 2022 Nobel Prize in chemistry for their work on a transformative scientific approach known as “click chemistry.” The three scientists will receive their awards during a ceremony in Stockholm, Sweden, on December 10, 2022.

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Dynamic Duo Degrees: NIGMS-Funded Programs Support M.D./D.V.M.-Ph.D. Training

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Amelia Wilhelm wearing a white doctor’s coat and posing outside in front of sunflowers.
Amelia Wilhelm. Credit: Courtesy of Amelia Wilhelm.

“Being able to ground your research in questions coming directly from your patients and their families is so meaningful and a huge part of why I’m interested in becoming a clinician-scientist,” says Amelia Wilhelm, an M.D.-Ph.D. student in the NIGMS-supported Medical Scientist Training Program (MSTP) at the University of Washington in Seattle. MSTPs prepare students to combine clinical practice and rigorous scientific research in their future careers.

Continuing the Family Tradition in Science

As a child of two scientists, Amelia was exposed to research and medical careers from an early age. She earned a bachelor’s degree in chemistry at Bates College in Lewiston, Maine, and then began working as a lab technician at the Children’s Hospital of Philadelphia in Pennsylvania. Watching the principal investigator of her lab, clinician-scientist Lindsey A. George, M.D., interact with patients inspired Amelia to pursue a similar career.

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Empowering Biomedical Research in Rural West Virginia

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Public health crises often disproportionately impact rural America. Sally L. Hodder, M.D., works to alleviate these disparities, especially regarding the opioid crisis and the COVID-19 pandemic. She’s the director of the West Virginia Clinical and Translational Science Institute (WVCTSI), the associate vice president of clinical and translational research, and a professor of medicine at West Virginia University.

A headshot of Dr. Sally Hodder.
Dr. Sally Hodder. Credit: West Virginia University.

Dr. Hodder’s work is focused in West Virginia, but her results are valuable assets to researchers across the country. Not only does treating chronic diseases in rural populations contribute to the overall understanding of those diseases, but engaging with and involving people in those communities in research makes science more accessible to them. Dr. Hodder says, “When folks participate in the science, when there is good community discussion about the trial designs and the results, then I think those populations may be more trusting of the results.”

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Sparking Rural Students’ Interest in STEM

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When asked why he leads the NIGMS-supported Science Education Partnership Award (SEPA) program at Dartmouth College in Hanover, New Hampshire, Roger D. Sloboda, Ph.D., the Ira Allen Eastman Professor of Biological Sciences (emeritus), shares a story. Several years ago, he learned of a public-school science teacher in rural New Hampshire who had a very limited budget for classroom equipment. With her annual budget, she’d been able to buy a single stainless-steel laboratory cart. “Next year, I hope to buy a piece of equipment to put on it,” she said. A short time later, Dr. Sloboda attended a scientific meeting and talked to a student from a private school in Washington, D.C., who was presenting a poster about his research project studying the effects of household chemicals on zebrafish development. Dr. Sloboda asked the student how he was able to work with zebrafish, because they require specialized, expensive facilities. The student responded that his school maintained its own zebrafish facility.

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Advancing American Indian and Alaska Native Health Through Research, Training, and Engagement

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American Indian and Alaska Native (AI/AN) populations have long experienced health disparities such as higher rates of diabetes, certain cancers, and mental health conditions than those of other Americans. One contributing factor in these disparities is underrepresentation of AI/AN populations in biomedical science—as study participants, researchers, and health professionals. Unfamiliarity with health care options and opportunities, coupled with a distrust of biomedical research resulting from unethical studies in the past, have exacerbated this underrepresentation.

NIGMS-supported researchers, including Native scientists, are partnering with AI/AN Tribes to help reduce health disparities by conducting research focused on AI/AN health priorities and building infrastructure that supports research in those communities. They’re also preparing Native students to pursue careers in science and medicine. In this post, you’ll meet four scientists advancing AI/AN health.

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Quiz: Antibiotic Resistance and Researchers Studying It

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Antibiotics are a class of drugs that treat bacterial infections. They may seem common now, but they were discovered less than a century ago. In 1928, Alexander Fleming, a scientist studying bacteria, found that mold from his bread kept bacteria from growing. He determined that “mold juice” was able to kill different types of harmful bacteria, and he and his assistants worked to figure out what natural product in the mold was actually causing the killing. It turned out to be penicillin!

Thanks to Fleming’s discovery, doctors have been successfully treating bacterial infections with penicillin and other newer antibiotics. But in recent years, some infections that were once treatable with antibiotics no longer respond to them. Some of these infections can be treated with multiple rounds of different antibiotic treatments, but others aren’t treatable at all—even leading to death in some cases.

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National Chemistry Week: Recent Interviews With NIGMS-Funded Chemists

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Logo that says, “National Chemistry Week,” with a test tube in place of the letter i in the word “chemistry. Credit: ACS Website.

It’s almost National Chemistry Week (NCW)! Each year, the American Chemical Society (ACS) unites scientists, undergraduate students, high school chemistry clubs, and other groups through this community-based program to reach the public—especially elementary and middle school
students—with positive chemistry messages.

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San Diego Postdoctoral Scholars Program Enhances Diversity in Biomedical Research

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“I’m most proud of how this program is truly impacting the diversity of academia by including individuals from backgrounds historically underrepresented in STEM and the biomedical research workforce,” says JoAnn Trejo, Ph.D., professor at University of California San Diego (UCSD) and director of San Diego’s Institutional Research and Academic Career Development Award (IRACDA). The program, now in its 20th year of NIGMS funding, aims to train a diverse group of postdoctoral fellows (postdocs) for both the teaching and independent research aspects of a career as a professor in the biomedical sciences.

A group of 19 people standing together and smiling.
San Diego IRACDA program participants from 2018 (left) and 2022 (right). Credit: Courtesy of Dr. JoAnn Trejo.

The San Diego IRACDA focuses on preparing its fellows for tenure-track positions at different types of institutions, including research-intensive universities. Fellows typically go through a 3-year program where they work in a research lab at UCSD, teach at one of the two “partner” schools (both of which are minority-serving institutions), and take career development courses in skillsets like effectively mentoring, running a cutting-edge research lab, and innovatively redesigning undergraduate science courses. Fellows also mentor students at the partner schools, helping them prepare graduate school applications, putting them through mock interviews, educating them in research, and teaching them how to read and understand scientific literature.

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Studying and Sharing the Big Questions of Biology

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A headshot of Dr. Márquez-Zacarías.
Dr. Pedro Márquez-Zacarías. Credit: Courtesy of Dr. Pedro Márquez-Zacarías.

When he started high school in Mexico, Pedro Márquez-Zacarías, Ph.D., wanted to be a politician. However, as he became aware of issues like corruption, he began looking into other fields. Chemistry fascinated him, so he enrolled in a class at his school that was later canceled partway through the year. He then joined a biology class because it included a unit on biochemistry, and through that experience, found that he enjoyed other aspects of biology as well—so much so that he went on to compete in the International Biology Olympiad, a competition for high school biology students.

After graduating from high school, Dr. Márquez-Zacarías majored in biomedical sciences at Universidad Nacional Autónoma de México and discovered a passion for ecology and evolution. During a class activity where students had to present scientific papers, the work of evolutionary biologist William Croft Ratcliff, Ph.D. riveted him. Dr. Márquez-Zacarías began an email conversation with Dr. Ratcliff that led to visiting his NIGMS-supported lab at the Georgia Institute of Technology (Georgia Tech) in Atlanta.

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