Biomedical Beat Blog – National Institute of General Medical Sciences
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You might first think about sports when you hear the word base, but not all bases are on the baseball diamond. In chemistry, a base is a molecule that reacts with an acid, often by accepting a proton from the acid or from water. Baking soda and dish soap are common bases.
“An important part of being in science is being in a community,” says Neil Garg, Ph.D., Distinguished Professor and chair of the department of chemistry and biochemistry at the University of California Los Angeles (UCLA). That philosophy has led him to prioritize mentorship, diversity, and inclusion—while maintaining research excellence—as well as re-envisioning what it means to educate students and the public.
Falling in Love With Chemistry
Science was always a part of Dr. Garg’s childhood. He participated in science fairs as a kid but says he did it for the community and not necessarily for the love of science. “When I look back on those projects, they were always with friends—never by myself,” he says. His parents were both scientists and strongly encouraged him to go into medicine, and although he became a premed major at New York University (NYU), he ultimately chose a different path.
Continue reading “Innovating Education, Outreach, and Mentorship With Organic Chemist Neil Garg”
Students with blindness and low vision are often excluded from chemistry labs and offered few accessible representations of the subject’s imagery, which can significantly hinder their ability to learn about and participate in chemistry. Bryan Shaw, Ph.D., a professor of chemistry and biochemistry at Baylor University in Waco, Texas, hopes to change that through a program funded by an NIGMS Science Education Partnership Award (SEPA). His inspiration to start the program came from his son, who is visually impaired due to childhood eye cancer, and his son’s friends who have also experienced partial or complete vision loss.
Continue reading “Students With Visual Impairments Empowered to Explore Chemistry Through SEPA Project”
Someone’s hand moving to scroll through this blog post is possible because of a mineral that both gives bones their strength and allows muscles to move: calcium. As the most abundant mineral in our bodies, it’s essential for lots of important functions. It’s found in many foods, medicines, and dietary supplements.
Calcium keeps your bones strong, allows your muscles to move, and is important for many other bodily functions. The element is found in foods, medicines, and the world around us. Credit: Compound Interest CC BY-NC-ND 4.0. Click to enlarge.
You may know that antioxidants can help protect your cells from oxidative damage, but do you know about selenium—an element often found in special proteins called antioxidant enzymes? Selenium is essential to your body, which means you must get it from the food you eat. But it’s a trace element so you only need a small amount to benefit from its effects. In addition to its antioxidant properties, it’s also important for reproduction, DNA synthesis, and hormone metabolism.
Continue reading “So Much to Do, So Little Selenium Needed”
Since its creation in 1962, NIGMS has supported the work of the recipients of 94 Nobel Prizes—44 in physiology or medicine and 50 in chemistry. NIGMS-funded investigators perform cutting-edge basic research that is foundational to understanding normal life processes and disease. Such important breakthroughs in chemistry and biology often fuel more focused research that, years later, leads to important medical advances or products such as medicines or biotechnology tools.
The most recent NIGMS-supported Nobel laureates are Carolyn R. Bertozzi, Ph.D., the Anne T. and Robert M. Bass Professor in the School of Humanities and Sciences at Stanford University in Stanford, California, and K. Barry Sharpless, Ph.D., the W.M. Keck Professor of Chemistry at the Scripps Research Institute in La Jolla, California. They, along with Morten Meldal, Ph.D., a professor of chemistry at the University of Copenhagen in Denmark, are being recognized with the 2022 Nobel Prize in chemistry for their work on a transformative scientific approach known as “click chemistry.” The three scientists will receive their awards during a ceremony in Stockholm, Sweden, on December 10, 2022.
Continue reading “The Chemistry Clicked: Two NIGMS-Funded Researchers Receive Nobel Prize”
Just as electricity powers almost every modern gadget, the tiny molecule adenosine triphosphate (ATP) is the major source of energy for organisms’ biochemical reactions. ATP stores energy in the chemical bonds that hold its three phosphate groups together—the triphosphate part of its name. In the human body, ATP powers processes such as cell signaling, muscle contraction, nerve firing, and DNA and RNA synthesis. Because our cells are constantly using and producing ATP, each of us turns over roughly our body weight in the molecule every day!
Our bodies can produce ATP in several ways, but the most common is cellular respiration—a multistep process in which glucose molecules from our diet and oxygen react to form water and carbon dioxide. The breakdown of a single molecule of glucose in this way releases energy, which the body captures and stores in around 32 ATP molecules. Along with oxygen, mitochondria are crucial for producing ATP through cellular respiration, which is why they’re sometimes called the powerhouses of cells.
Continue reading “Science Snippet: ATP’s Amazing Power”
When we encounter the word mole, some of us might think of a small, fuzzy animal that burrows in gardens, or perhaps the common, pigmented marks on our skin. But in chemistry, the mole is a key unit of measurement; its name is derived from the word molecule. Similar to how “dozen” is another way of saying 12, “mole” is another way of saying 602,214,076,000,000,000,000,000 (that’s about 602 billion trillion), specifically for elementary entities such as molecules and atoms. Scientists sometimes abbreviate this number as 6.02 x 1023, which is why Mole Day is celebrated from 6:02 a.m. to 6:02 p.m. on October 23 each year.
Credit: ACS Website.
It’s almost National Chemistry Week (NCW)! Each year, the American Chemical Society (ACS) unites scientists, undergraduate students, high school chemistry clubs, and other groups through this community-based program to reach the public—especially elementary and middle school
students—with positive chemistry messages.
“Science provides adventure and excitement every single day. When you’re pushing boundaries, you get to jump into the abyss of new areas. It can be scary, but it’s an incredible opportunity to try to improve our world and people’s lives,” says César de la Fuente, Ph.D., a Presidential Assistant Professor in the Perelman School of Medicine and School of Engineering and Applied Science at the University of Pennsylvania, Philadelphia. Our interview with Dr. de la Fuente highlights his journey of becoming a scientist and his research using artificial intelligence to discover new drugs.
Q: How did you first become interested in science?
A: I’ve always been fascinated by the world around me. I grew up in a town in northwest Spain, right on the Atlantic Ocean. As a kid, I would go to the beach to investigate marine organisms and bring home all sorts of different fish to study. My mom wasn’t too happy about that! We’re all born scientists, but we tend to lose that curiosity as we enter adulthood. The key is to not lose our ability to learn every day.
Continue reading “Career Conversations: Q&A With Bioengineer César de la Fuente”