Category: Being a Scientist

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Pathways: The Regeneration Issue

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Cover of Pathways student magazine showing many zebrafish swimming underwater around grasslike plants, with the featured question: What do you and these zebrafish have in common? Cover of Pathways student magazine.

NIGMS and Scholastic, Inc., are excited to bring you the next edition of Pathways, a collection of free resources that teaches students about basic science, its importance to human health, and exciting research careers.

Pathways is designed for grades 6 through 12. The topic of this unit is regenerative medicine, a field that focuses on restoring or healing damaged body parts so that they function normally. The long-term goal is to stimulate tissue and organs to heal themselves.

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On the RISE: Joshua and Caleb Marceau Use NIGMS Grant to Jump-Start Their Research Careers

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A college degree was far from the minds of Joshua and Caleb Marceau growing up on a small farm on the Flathead Indian Reservation in rural northwestern Montana. Their world centered on powwows, tending cattle and chicken, fishing in streams, and working the 20-acre ranch their parents own. Despite their innate love of learning and science, the idea of applying to and paying for college seemed out of reach. Then, opportunities provided through NIGMS, mentors, and scholarships led them from a local tribal college to advanced degrees in biomedical science. Today, both Joshua and Caleb are Ph.D.-level scientists working to improve public health through the study of viruses.

Joshua Discovers Unexpected Opportunities

Joshua Marceau examining a specimen in front of a large centrifuge.Joshua Marceau at Salish Kootenai College, where he gained research experience as an undergraduate. Credit: Joshua Marceau.

As the oldest of four brothers, Joshua was the trailblazer in the family. But like most trailblazers, his path to a scientific career wasn’t always smooth. He attended a reservation school until sixth grade, then was homeschooled. He earned his GED through the local tribal community college, Salish Kootenai College (SKC) in Pablo, so he could begin to take college-level chemistry.

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Back to School: Top Tips for Undergraduates Eyeing Careers in Biomedical Sciences

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Finding a career path in biomedical research can be challenging for many young people, especially when they have no footsteps to follow. We asked three recent college graduates who are pursuing advanced degrees in biomedical sciences to give us their best advice for undergrads.

Tip 1: Talk with mentors and peers, and explore opportunities.

One of the most challenging things for incoming undergraduates is simply to find out about biomedical research opportunities. By talking to professors and peers, students can find ways to explore and develop their interests in biomedical research.

Mariajose Franco in a lab, using a pipette to fill a glass vial.Credit: Michele Vaughan.

Mariajose Franco, a first-generation college student, recently graduated with honors and dual degrees in molecular and cellular biology and physiology from the University of Arizona in Tucson. She’s now in a postbaccalaureate program at the National Cancer Institute and has her eye on combined M.D.-Ph.D. programs.

As an undergraduate, a course in cancer biology piqued her interest, and she reached out to her professor, Justina McEvoy, to see if she could join her lab. As a sophomore, Franco began working on rhabdomyosarcoma, a rare childhood cancer that arises from cells that normally develop into skeletal muscle. Through the NIGMS Maximizing Access to Research Careers (MARC) program, she received support to conduct two research projects during her junior and senior years. In addition to offering research opportunities, the MARC program was instrumental in providing training in scientific writing and conference poster presentations, and navigating applications, Franco says.

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Get Kids Excited About Science: Free STEM Resources

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Cover of the graphic novel Occupied by Microbes!, showing four teens racing downhill on skateboards. Credit: University of Nebraska, Lincoln.

We have a new Science Education and Partnership Award (SEPA) webpage, featuring free, easy-to-access, SEPA-funded resources that educators nationwide can use to engage their students in science. The SEPA program supports innovative STEM and informal science education projects for pre-kindergarten through grade 12. The program includes tools that teachers, scientists, and parents can use to excite kids about science and research, such as:

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A Scientist’s Exploration of Regeneration

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Viravuth (“Voot”) Yin, standing with arms crossed and smiling in front of a shelves holding tanks of zebrafish in his lab. Viravuth (“Voot”) Yin, associate professor of regenerative biology and medicine at MDI Biological Laboratory and chief scientific officer at Novo Biosciences, Inc., in Bar Harbor, Maine. Credit: MDI Biological Laboratory.

In 1980, a week after his 6th birthday, Viravuth (“Voot”) Yin immigrated with his mother, grandfather, and three siblings from Cambodia to the United States. Everything they owned fit into a single, 18-inch carry-on bag. They had to build new lives from almost nothing. So, it’s perhaps fitting that Yin studies regeneration, the fascinating ability of some animals, such as salamanders, sea stars, and zebrafish, to regrow damaged body parts, essentially from scratch.

Yin’s path wasn’t always smooth. His family settled in Hartford, Connecticut, near an uncle who had been granted asylum during the Vietnam War. Yin got into a lot of trouble in school, trying to learn a new culture and fit in. Things improved when his mother moved him and his siblings to West Hartford, well known for its strong schools.

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Don’t Be Afraid to Search in the Dark: NIGMS Director Jon Lorsch Encourages College Grads to Consider New Perspectives

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Jon Lorsch, from Swarthmore College’s class of 1990, returned to his alma mater in May to accept an honorary Doctor of Sciences degree for his accomplishments as a biochemist and his visionary leadership of NIGMS. During the university’s 147th commencement, he spoke to the 2019 graduating class, offering advice and examples of how we can look for opportunities in the least likely places.

Watch the 5-minute video to hear Lorsch’s advice to the graduates—and all future scientists—to venture into the unknown in search of the next big advance in biomedical research.

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Computational Biologist Melissa Wilson on Sex Chromosomes, Gila Monsters, and Career Advice

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Melissa Wilson wearing a floral dress and speaking beside a podium during her lecture. Dr. Melissa Wilson.
Credit: Chia-Chi Charlie Chang.

The X and Y chromosomes, also known as sex chromosomes, differ greatly from each other. But in two regions, they are practically identical, said Melissa Wilson, assistant professor of genomics, evolution, and bioinformatics at Arizona State University.

“We’re interested in studying how the process of evolution shaped the X and the Y chromosome in gene content and expression and how that subsequently affects literally everything else that comes with being a human,” she said at the April 10 NIGMS Director’s Early-Career Investigator (ECI) Lecture at NIH.

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PREP Scholar’s Passion for Understanding Body’s Defenses

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Photo of Charmaine Nganje, with curly red shoulder-length hair and eyeglasses, smiling..

Charmaine N. Nganje, PREP scholar at Tufts University in Boston.
Credit: Katherine Suarez.

Charmaine N. Nganje

Hometown: Montgomery Village, Maryland

Influential book : The Harry Potter series (not exactly influential, but they’re my favorite)

Favorite movie/TV show: The Pursuit of Happyness/The Flash

Languages: English (and a bit of Patois)

Unusual fact: I’m the biggest Philadelphia Eagles fan from Maryland that you’ll ever meet

Hobbies: Off-peak traveling

Q. Which NIGMS program are you involved with?

A. The Postbaccalaureate Research Education Program (PREP) at the Sackler School of Graduate Biomedical Sciences at Tufts University in Boston.

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