Tag: Training

All About Grants: Basics 101

2 comments

Note to our Biomedical Beat readers: Echoing the sentiments NIH Director Francis Collins made on his blog, NIGMS is making every effort during the COVID-19 pandemic to keep supporting the best and most powerful science. In that spirit, we’ll continue to bring you stories across a wide range of NIGMS topics. We hope these posts offer a respite from the coronavirus news when needed.

A female scientist in a lab using a pipette. Scientific research requires many resources, which all require funding.
Credit: Michele Vaughan.

Scientific inspiration often strikes unexpectedly. The Greek mathematician and inventor Archimedes first thought of the principles of volume while taking a bath. Otto Loewi designed an important experiment on nerve cells based on a dream involving frog hearts.

But going from an initial moment of inspiration to a final answer can be a long and complex process. Scientific research requires many resources, including laboratory equipment, research organisms, and scientists’ time. And all of this requires funding. Government grants support the majority of research in the United States, and the main source of these grants for biomedical researchers is the National Institutes of Health (NIH). NIH is the primary federal agency for conducting and supporting basic, clinical, and translational medical research. It investigates the causes, treatments, and cures for both common and rare diseases.

Continue reading “All About Grants: Basics 101”

Crowdsourcing Science: Using Competition to Drive Creativity

0 comments
Six student researchers sitting around a table and collaborating on a project. Credit: iStock.

Historically, crowdsourcing has played an important role in certain fields of scientific research. Wildlife biologists often rely on members of the public to monitor animal populations. Using backyard telescopes, amateur astronomers provide images and measurements that lead to important discoveries about the universe. And many meteorologists use data collected by citizen scientists to study weather conditions and patterns.

Now, thanks largely to advances in computing, researchers in computational biology and data science are harnessing the power of the masses and making discoveries that provide valuable insights into human health.

Continue reading “Crowdsourcing Science: Using Competition to Drive Creativity”

PECASE Honoree Elizabeth Nance Highlights the Importance of Collaboration in Nanotechnology

0 comments
Black and white microscopic image of a capillary supplying blood to brain cells. A network of capillaries supplies brain cells with nutrients. Tight seals in their walls keep blood toxins—and many beneficial drugs—out of the brain. Credit: Dan Ferber, PLOS Biol 2007 Jun; (5)6:E169. CC by 2.5 Link to external web site.

The blood-brain barrier—the ultra-tight seal in the walls of the brain’s capillaries—is an important part of the body’s defense system. It keeps invaders and other toxins from entering the human brain by screening out dangerous molecules. But the intricate workings of this extremely effective barrier also make it challenging to design therapeutics that would help us. And as it turns out, getting a drug across the blood-brain barrier is only half the battle. Once it’s across, the drug needs to effectively target the right cells in the brain tissue. With this in mind, it’s no surprise that challenges this complex are solved through collaboration among scientists from several different specialties.

Elizabeth Nance Link to external web site, an assistant professor of chemical engineering at the University of Washington in Seattle and a recent recipient of the Presidential Early Career Award for Scientists and Engineers (PECASE), focuses her research on understanding the barriers in the brain and other cell- and tissue-based barriers in the body to see how nanoparticles interact with them. Her lab uses nanoparticles to package therapies that will treat newborn brain injury, which can occur when the brain loses oxygen and blood flow, often during or immediately prior to delivery. This damage can lead to cerebral palsy, developmental delays, or sometimes death. Early interventions for newborn brain injury can be valuable, but they need to target specific, injured cells without harming healthy ones.

Continue reading “PECASE Honoree Elizabeth Nance Highlights the Importance of Collaboration in Nanotechnology”

On the RISE: Joshua and Caleb Marceau Use NIGMS Grant to Jump-Start Their Research Careers

0 comments

A college degree was far from the minds of Joshua and Caleb Marceau growing up on a small farm on the Flathead Indian Reservation in rural northwestern Montana. Their world centered on powwows, tending cattle and chicken, fishing in streams, and working the 20-acre ranch their parents own. Despite their innate love of learning and science, the idea of applying to and paying for college seemed out of reach. Then, opportunities provided through NIGMS, mentors, and scholarships led them from a local tribal college to advanced degrees in biomedical science. Today, both Joshua and Caleb are Ph.D.-level scientists working to improve public health through the study of viruses.

Joshua Discovers Unexpected Opportunities

Joshua Marceau examining a specimen in front of a large centrifuge.Joshua Marceau at Salish Kootenai College, where he gained research experience as an undergraduate. Credit: Joshua Marceau.

As the oldest of four brothers, Joshua was the trailblazer in the family. But like most trailblazers, his path to a scientific career wasn’t always smooth. He attended a reservation school until sixth grade, then was homeschooled. He earned his GED through the local tribal community college, Salish Kootenai College (SKC) in Pablo, so he could begin to take college-level chemistry.

Continue reading “On the RISE: Joshua and Caleb Marceau Use NIGMS Grant to Jump-Start Their Research Careers”

Back to School: Top Tips for Undergraduates Eyeing Careers in Biomedical Sciences

0 comments

Finding a career path in biomedical research can be challenging for many young people, especially when they have no footsteps to follow. We asked three recent college graduates who are pursuing advanced degrees in biomedical sciences to give us their best advice for undergrads.

Tip 1: Talk with mentors and peers, and explore opportunities.

One of the most challenging things for incoming undergraduates is simply to find out about biomedical research opportunities. By talking to professors and peers, students can find ways to explore and develop their interests in biomedical research.

Mariajose Franco in a lab, using a pipette to fill a glass vial.Credit: Michele Vaughan.

Mariajose Franco, a first-generation college student, recently graduated with honors and dual degrees in molecular and cellular biology and physiology from the University of Arizona in Tucson. She’s now in a postbaccalaureate program at the National Cancer Institute and has her eye on combined M.D.-Ph.D. programs.

As an undergraduate, a course in cancer biology piqued her interest, and she reached out to her professor, Justina McEvoy, to see if she could join her lab. As a sophomore, Franco began working on rhabdomyosarcoma, a rare childhood cancer that arises from cells that normally develop into skeletal muscle. Through the NIGMS Maximizing Access to Research Careers (MARC) program, she received support to conduct two research projects during her junior and senior years. In addition to offering research opportunities, the MARC program was instrumental in providing training in scientific writing and conference poster presentations, and navigating applications, Franco says.

Continue reading “Back to School: Top Tips for Undergraduates Eyeing Careers in Biomedical Sciences”

Get Kids Excited About Science: Free STEM Resources

0 comments
Cover of the graphic novel Occupied by Microbes!, showing four teens racing downhill on skateboards. Credit: University of Nebraska, Lincoln.

We have a new Science Education and Partnership Award (SEPA) webpage, featuring free, easy-to-access, SEPA-funded Link to external web site resources that educators nationwide can use to engage their students in science. The SEPA program supports innovative STEM Link to external web site and informal science education Link to external web site  projects for pre-kindergarten through grade 12. The program includes tools that teachers, scientists, and parents can use to excite kids about science and research, such as:

Continue reading “Get Kids Excited About Science: Free STEM Resources”

PREP Scholar’s Passion for Understanding Body’s Defenses

1 comment
Photo of Charmaine Nganje, with curly red shoulder-length hair and eyeglasses, smiling..

Charmaine N. Nganje, PREP scholar at Tufts University in Boston.
Credit: Katherine Suarez.

Charmaine N. Nganje

Hometown: Montgomery Village, Maryland

Influential book : The Harry Potter series (not exactly influential, but they’re my favorite)

Favorite movie/TV show: The Pursuit of Happyness/The Flash

Languages: English (and a bit of Patois)

Unusual fact: I’m the biggest Philadelphia Eagles fan from Maryland that you’ll ever meet

Hobbies: Off-peak traveling

Q. Which NIGMS program are you involved with?

A. The Postbaccalaureate Research Education Program (PREP) Link to external web site at the Sackler School of Graduate Biomedical Sciences at Tufts University in Boston.

Continue reading “PREP Scholar’s Passion for Understanding Body’s Defenses”

NIGMS Grantees Receive National STEM Mentoring Award

2 comments

In a previous post, we highlighted two NIGMS-funded winners of the 2018 Presidential Award for Excellence in Science, Mathematics and Engineering Mentoring (PAESMEM Link to external web site). For January’s National Mentoring Month, we tell you about other awardees: J.K. Haynes, Virginia Shepherd, and Maria da Graça H. Vicente.

Continue reading “NIGMS Grantees Receive National STEM Mentoring Award”

How Three Physician Scientists Are Taking Strides to Improve Our Health

0 comments

Brain injuries, cancer, infections, and wound healing are some of the complex and pressing health concerns we face today. Understanding the basic science behind these diseases and biological processes is the key to developing new treatments and improving patient outcomes. Physician scientists—medical doctors who also conduct laboratory research—are essential to turning knowledge gained in the lab into innovative treatments, surgical advances, and new diagnostic tools.

In this blog, we highlight the work and impact of three surgeon scientists funded by NIGMS at different stages in their careers: Dr. Nicole Gibran (current grantee), Dr. Rebecca Minter (former grantee), and Dr. Carrie Sims (former grantee). Their work, despite the historical underrepresentation of women in the physician scientist training community, has led to revolutionary surgical treatments, new therapeutics, better screening, and improved quality of life for patients.

Continue reading “How Three Physician Scientists Are Taking Strides to Improve Our Health”

Surgeon Chris McCulloh Stands Up to Disability

0 comments
Profile picture of Chris McCulloh with short, light brown hair and wearing a suit, smiling.
Credit: Chris McCulloh.
Chris McCulloh

Job: 4th-year general surgical resident, Morristown Medical Center in New Jersey
Grew up in: Manhattan
When not at work, he’s: Programming, coding, thinking about artificial intelligence, and machine learning
Hobbies: Writing/producing electronic music, weightlifting

Ten years ago, Chris McCulloh planned to enter medical school and fulfill his dream of becoming a surgeon. Instead, just months before he was to start med school, he ended up a patient. A freak accident—slipping on a hardwood floor, flying backwards, and landing neck-first on the edge of a glass coffee table—left him with both legs paralyzed at age 28. Undaunted, he deferred entering medical school for a year, undergoing surgery and spending months in rehab.

Chris McCulloh on a specialized wheelchair that holds him upright, wearing surgical scrubs and cap, in a hospital hallway alongside Elizabeth Vargas, also in scrubs and cap..
McCulloh prepares for surgery while “20/20” host Elizabeth Vargas stands alongside him as part of a 2017 interview.
Credit: Morristown Medical Center.

McCulloh has since finished medical school and recently completed a 2-year pediatric surgery research fellowship at Nationwide Children’s Hospital in Columbus, Ohio. He is now two-thirds of the way through his surgical residency at the Morristown (New Jersey) Medical Center, thanks to the assistance of a specialized wheelchair that allows him to stand nearly to his 6-foot-3 height and helps him perform five to six surgeries a day.

He’s received plenty of attention for being a surgeon with a disability. Along with several print media stories, he was interviewed in 2013 for CBS’ “The Doctors,” and in 2017, ABC’s “20/20” included McCulloh in an episode on physicians with disabilities. But it’s not the wheelchair that distinguishes McCulloh, says Gail Besner, a pediatric surgeon and researcher who hired McCulloh as a postdoctoral fellow. Rather, it’s his enthusiasm, natural research skills, and exceptional surgical prowess that make him special. Besner sees no reason why he won’t reach his goal of landing a highly competitive pediatric surgical residency. “I think he’s capable of doing anything he puts his mind to,” she says.

Continue reading “Surgeon Chris McCulloh Stands Up to Disability”